Prostate Cancer Genes

Prostate cancer genes,

Males, who, have a father, or brother,

with prostate, cancer,have twice, the risk, of developing,

cancer,studies, of twins, in Scandinavia,suggest,that 40%,

of cancer,many different,genes,have been implicated,

Mutation, in BRCA1, and BRCA2, gene,

loss, of cancer, suppressor, gene,

up to70%, of males, with prostate-cancer,

Have ,lost, one, copy, of the PTEN, gene,at the time of

diagnosis.

frequency, of loss, of E-Cadheren, and CD44 gene,

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Suppressor Gene

frequency, of loss, of E-Cadheren, and CD44 gene,When normal,

cells, are damaged, beyond repair,

they are eliminated, by apoptosis,

Prostate-cancer, is classified, as a glandular, cancer,

Prostate cancer genes

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Inherited factors

When normal, cells, are damaged, beyond repair,

they are eliminated, by apoptosis,

Prostate-cancer, is classified, as a glandular, cancer,

that begins, when normal, semen-secreting, prostate,

gland cells, mutate ,into cancer cells,

The region, of prostate, gland, where the adenocarcinoma,

is most common, is the peripheral zone,

Initially, small clumps, of cancer cells, remain, confined,

to otherwise, normal, prostate glands, a condition known,

as cancer,

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Malignancy

PCA3, has been shown, to predict, the presence, of malignancy,

in men, undergoing, repeat, prostate-biopsy,

but the first, prostate-biopsy', returns a normal, result,

This occurs, in approximately, 60%, of cases, and on repeat,

testing, 20-40%, have an abnormal, biopsy result,

A commercial, kit, called the Progensa, PCA3, test,

is marketed, by the Californian, company Gen-probe,

PCA3, was discovered, to be highly, expressed,

by prostate-cancer, cells, in 1999,

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