Multiple myeloma

Multiple, myeloma,(bone marrow), is a cancer, of plasma, cells,

a type, of white, blood, cell, normally, responsible,

for the production, of antibodies,

Collections, of abnormal, cells, accumulate, in bones,

where, they cause, bone lesions,

and bone, marrow, where,they interfere,

with the production, of normal, blood cells,

Most cases, of myeloma,

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Paraprotein

the production,of a paraprotein,

an abnormal, antibody, that can, cause, kidney, problems,

interferes, with the production, of normal, antibodies,

leading, to immunodeficiency,

Hypercalcemia, (high calcium levels),

is often encountered,

Multiple-Myeloma, is diagnosed, with blood tests,

(protein, electrophoresis, peripheral, blood, smear,)

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Diagnosed with Blood tests

microscopic, examination, of the bone, marrow,

(bone, marrow, biopsy),

and, X-rays, of involved, bones,

Multiple-Myeloma, is generally, thought, to be, incurable,

but, remissions, may, be, induced with steroids, chemotherapy,

thalidomide, and stem, cell, transplants,

Radiation, therapy, is sometimes, used, to treat, bone, lesions,

that are causing, symptoms,

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Release calcium in Blood stream

raised, calcium, (when osteoclasts, are breaking, down, bone,

releasing, calcium, into the bloodstream,)

raised serum, creatinine, due, to reduced, renal, function,

which is mainly, due,

to casts, of paraprotein, deposition, in the kidney,

although, the cast, may, also, contain,

complete, immunoglobulins,

protein, multiple-myeloma, can produce

all classes, of immunoglobulin,

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Bone marrow

Multiple, myeloma,(bone marrow,)

many, organs, can be affected, by multiple-myeloma,

the symptoms, and signs, vary greatly,

Calcium, (elevated), Renal, failure, Anemia, Bone, lesions,

multiple-Myeloma, has many possible, symptoms,

and all symptoms, may be due, to other causes,

Multiple myeloma

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