Multiple myeloma treatment

Multiple myeloma, treatment,

disease, containment, and suppression.

If the disease, is completely, paraprotein,

and an abnormal, bone marrow, population,

but no, end-organ, damage, treatment may be deferred.

addition to direct, treatment, of the plasma cells,

proliferation, bisphosphonates.

(e.g. pamidronate or zoledronic acid)

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Treatment

are administered, to prevent, fractures and

erythropoietin, to treat, anemia.

Initial treatment of multiple-myeloma depends on the patient’s

age. In recent years, high-dose, chemotherapy, with hematopoietic,

stem-cell, transplantation,

has become the preferred, treatment, for patients,

under, the age, of 65.

Prior to stem-cell, transplantation,

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Stem cell Transplantation

patients, receive, an initial, course of induction,

chemotherapy.

Autologous, stem cell, transplantation, (ASCT),

the transplantation, of a patient’s, own ,stem cells,

after chemotherapy,

usual type, of stem cell, transplantation,

for multiple-myeloma.

It is not curative, but does prolong, overall survival.

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Healthy Persons stem cells

Allogeneic, stem cell, transplantation,

the transplantation, of a healthy, person’s stem cells,

into the affected, patient,

has the potential, for a cure,

but is only, available, to a small percentage, of patients.

Patients, over age 65, and patients, with significant,

concurrent, illness,

often, cannot, tolerate, stem cell, transplantation.

For these patients, the standard of care, has been chemotherapy,

with melphalan, and prednisone.

Recent studies, among this population, suggest, improved,

outcomes, with new, chemotherapy, regimens.

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Survival

Treatment, with bortezomib, melphalan, and prednisone,

had an estimated, overall, survival, of 83% at 30 months,

lenalidomide, plus, low-dose, dexamethasone,

an 82% survival at 2 years

and melphalan, prednisone, and lenalidomide,

had a 90% survival at 2 years.

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