Multiple myeloma symptoms

multiple, Myeloma, symptoms, are Headache,visual, change,

weakness, confusion, and fatigue, due, to hypercalcemia,

pain,loss, of, bowel, or bladder, control,

(due, to involvement, of spinal, cord, leading, to cord,

compression,)or carpal, tunnel, syndrome,

The anemia, found, in myeloma, is usually, normocytic, and

normochromic.

It results, from, the replacement, of normal, bone, marrow,

Infiltrating, tumor, cells,

inhibition, of normal, red, blood, cell, production,

Renal, failure, may, develop, both acutely, and chronically,

It is commonly, due, to hypercalcemia,

It may, also be due, to tubular, damage, from excretion,

of light, chains, also called, Bence Jones, proteins,

which, can manifest, as the Fanconi, syndrome,

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Renal Failure

(type II, renal, tubular, acidosis),

recurrent, infections, (pyelonephritis), and local,

infiltration, of tumor, cells,

Risk, period, for the occurrence, of infection,

is in the initial, few months, after, the start,

of chemotherapy,

The increased, risk, of infection, is due, to immune,

deficiency, decreased, production, and increased, destruction,

of normal, antibodies,

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Myeloma bone pain

Myeloma, bone, pain, usually, involves, the spine, and ribs,

and worsens, with, activity,

Persistent, localized, pain, may indicate, a bone fracture,

vertebrae, may lead, to spinal, cord, compression,

Myeloma, bone, disease, is due, to the over, expression,

of Receptor, Activator,

bone, marrow, stroma,

bone, lesions, are lytic, in nature, and are seen,

in radiographs,

which may, show "punched-out", resorptive, lesions,

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Radiography

(including, the "pepper pot", appearance, of the skull, on

radiography),

The breakdown, of bone, also leads, to release, of calcium,

into the blood, leading, to hypercalcemia,

and its, associated, symptoms, Multiple myeloma symptoms Beautiful rose

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