Melanoma cancer

Melanoma cancer,the earliest, stage, starts when the

melanocytes, begin to grow out of control,

Melanocytes, are found, between, the outer layer, of the skin,

(the epidermis) and the next layer (the dermis),

This early stage, of the melanoma, cancer, is called the radial,

growth, phase, and the tumor, is less, than 1mm thick,

Because, the cells, have not, yet, reached, the blood, vessels,

lower down, in the skin, it is very unlikely, that this early,

stage, will spread, to other parts, of the body,

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Tumor Stage

If the tumor,is detected, at this stage, then it can usually,

be completely, removed, with surgery,

When the cancer, cells, start,to move, in different, direction,

vertically, up, into the epidermis, and into the papillary,

dermis,the behaviour, of the cells, changes, dramatically,The

next step,in the evolution,is the invasive, radial, growth

phase, when individual, cells, start, to acquire, invasive,

potential, from this point, on the cancer, is capable,

of spreading,

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Cancer spreading

The Breslow's depth, of the lesion, is usually, less, than 1 mm

(0.04 in), the Clark, level is usually 2.

The following step,in the process,is the invasive, tumor, — the

vertical, growth, phase, (VGP).The tumor, attains invasive,

potential, meaning, it can grow, into the surrounding, tissue,

and can spread, around the body, through blood,

or lymph vessels,

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Regression

The tumor,thickness,is usually, more than 1 mm, (0.04 in),

and, the tumor, involves, the deeper, parts, of the dermis,

The host, elicits, an immunological, reaction, against,

the cancer,(during the VGP),

which is judged, by the presence, and activity, of the TILs,

(tumor, infiltrating, lymphocytes,)

These cells, sometimes, completely, destroy, the primary,

tumour, this is called, regression,

which is the latest, stage, of the cancer, development,

In certain cases, the primary cancer, is completely destroyed,

and only the metastatic, tumor, is discovered,

In some cases,cancer runs, in families,

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