Glioblastoma multiforme

Glioblastoma multiforme,

surgery, is the first,treatment,

average, tumor, contains, 1011 cells,

average, reduced, to 109, cells,

after, surgery, (a reduction of 99%),

take, section, for a pathological, diagnosis,

to remove, some,symptoms,

large, mass, pressing, against, the brain,

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Radiotherapy and Chemotherapy

to remove, disease, before secondary, resistance, to

radiotherapy, and chemotherapy, and to prolong, survival,

greater, the extent, of tumor,removal,the better,

Removal, of 98%,, or more, of the tumor, has been, associated,

significantly, longer, healthier, time,

if less than 98%, of the tumor, is removed,

near-complete, initial, removal, of the tumor,

can be greatly, increased ,if the surgery,

is guided, by a fluorescent, dye, known, 5-aminolevulinic, acid,

Glioblastoma, multiforme, cells,

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Removal of tumor

infiltrative, through, the brain, at diagnosis,

despite, a "total resection", of all obvious, tumor,

people, with GBM, later develop, recurrent, tumors,

either, near the original, site, or at more distant,

"satellite lesions", within, the brain,

Other, modalities, including, radiation, are used after surgery,

to suppress, and slow, recurrent, disease,chemotherapy,

Gross, total, resection, of tumor, is associated, with

a better, prognosis,

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Palliative treatment

Palliative, treatment, usually, is conducted,

to improve, quality, of life,

achieve, a longer, survival, time,

It includes, surgery, radiation, therapy, and chemotherapy,

A maximally, feasible, resection,

with maximal, tumor-free, margins, is usually, performed,

along, with, external, beam, radiation, and chemotherapy,

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Disease-free Enviroment

Long-term, disease-free, environment, is possible,

but, the tumor, usually,reappears,

often, within, 3 cm, of the original, site,

and 10–20%, may, develop, new lesions, at distant sites,

More, extensive, surgery, and intense, local treatment,

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Stem Cells
Recurrence, has been, associated, with improvement,

Relapse, of glioblastoma-multiforme, is attributed

to the recurrence,and Resistance, of tumor, stem cells,

Tumor B-cell, hybridoma, vaccine,

against, tumor, stem cells, elicited, a specific,

tumor, immune, reaction, enhancing, immune, response,

to the disease,