HIV acute infection

HIV acute infection,

occurs, by introduction, of bodily, fluids,

from, an infected, person,

into the body, of an uninfected, person,

formation, of viruses, target, host, cells,

Viruses, must first, get, into, the cell,

before, viral, replication, can, occur,

A cytotoxic, T cell, ( CD8+ T-cells, or killer T cell,)

(a type of white, blood, cell,) that are capable,

of inducing, the death, of infected, tumor,

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Virus in Blood

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HIV acute infection,

leading, to an abundance, of virus, in the blood,

During, primary, infection, the level, of HIV,

reach, several, million, virus, particles,

per milliliter, of blood,

HIV, acute, infection,

This viremia, is in all patients, with the

activation, of CD8+ T, cells, which kill, HIV-infected, cells,

and subsequently, with antibody, production,

or seroconversion,( blood testing, for anti-HIV antibodies,

"seroconverted", having "become HIV positive,)

CD8+ T, cell, response, is important in

controlling, virus,levels,

which, peak,and then decline,

as the CD4+ T, cell, counts, rebound,
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Linked to slower Progression

HIV acute infection

A good, CD8+ T, cell ,response, linked, to slower, progression,

and a better, prognosis,

though it does, not, eliminate, the ,virus,

During, this period, (usually 2–4 weeks, post-exposure,)

most people (80 to 90%,) develop,

an influenza, or mononucleosis-like, illness,

called acute, HIV, infection, the symptoms, include:

fever, lymphadenopathy, pharyngitis, rash, myalgia, malaise,

mouth, and esophageal, sores, headache, nausea, and vomiting,

enlarged, liver,/spleen, weight, loss, thrush,

and neurological, symptoms,

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Symptoms Varie

Infected, people, may experience, all, some, or none,

of these symptoms,

The duration, of symptoms, varies, averaging, 28 days,

and usually, lasting at least a week,

Because, of the nonspecific,nature of these symptoms,

they are often not, recognized, as signs, of HIV, infection,

Even if patients, go to their doctors, or a hospital,

they will often, be misdiagnosed, as having ,one, of the more

common, infectious, diseases, with the same, symptoms,


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As, a consequence, these, primary, symptoms, are not used,

to diagnose, HIV infection,

as they do not develop, in all cases,

and many, are caused, by other, more common, diseases,

recognizing, the syndrome, is important,

because, the patient, is much more infectious, during this period.

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